SIXTH
CONFERENCE
ON
THE
ADRENAL
CORTEX
September 21-24, 1994
Lake Murray Country Inn
and Resort
Ardmore, Oklahoma
SCIENTIFIC
PROGRAM
SCHEDULE
Thursday, September 22
8.45 Opening Remarks
PARACRINE EFFECTS ON THE ADRENAL CORTEX
Chair: Simon Walker (Edinburgh, UK)
8.50 Gavin Vinson (London, UK) Cellular interactions in the rat adrenal cortex
9.15 Stefan Bornstein (Leipzig, GERMANY) Sympathoadrenal regulation of adrenal steroidogenesis
9.40 Andrea Gwosdow (Boston, MA, USA) Mechanism of interleukin-1 induced corticosterone secretion from the rat adrenal gland
10.05 Ida Toth (Lexington, KY, USA) Modulation of the mammalian adrenocortical function by neuropeptides
10.30 BREAK
GROWTH & DEVELOPMENT OF ADRENAL CORTICAL FUNCTION
Chair. Ian Mason (Dallas, TX, USA)
11.00 Richard Parker (Birmingham, AL, USA) Immunohistochemical evaluation of the ontogeny of cortical and medullary elements of the human adrenal gland
11.25 Marelyn Wintour (Parkville, Victoria, AUSTRALIA) Regulation and function of fetal adrenal development in sheep
11.50 Chris Kenyon (Glasgow, Scotland, UK) In vivo studies of the control of cell division throughout the adrenal gland
12.15 Diane Keeney (Nashville, TN, USA) Embryonic expression of Cyp11A and adrenodoxin transcripts in steroidlogenic and non-sterodogenic tissues of the mouse
12.40 LUNCH BREAK
13.30 - 14:15 POSTER PRESENTATIONS
ACTH AND ANGII RECEPTORS
Chair: Bill Rainey (Dallas,TX, (USA)
15.00 Bernard Schimmer (Toronto, Ontario, CANADA)
ACTH-resistant mutants of the Yl adrenal cell line that fail to express the ACTH receptor
15.25 Jose Saez (Lyon, FRANCE)
Regulation of ACTH receptor binding sites and mRNA levels by peptide hormones and growth factors in human and bovine adrenocortical cells
15:50 Kevin Caft (Bethesda, MD, USA)
Adrenal angiotensin II receptors: ligand binding, signaling, and internalization
16.15 Ian Bird (Madison, WI, USA)
Angiotensin II type 1 receptor and mRNA levels are regulated through
multiple signalling pathways in the human adrenocortical H295R cells
16:40 BREAK
FACILITY OF ACUTE STEROIDOGENESIS
Chair: Alastair Brownie (Buffalo, NY, USA)
16.55 Sandra Murray (Pittsburgh, PA, USA)
Characterization of gap junction expression in mammalian adrenal glands
17.20 Israel Hanukoglu (Rehovot, ISRAEL)
Does NADPH supply to the mitochondrial P450 systems depend on substrate availability?
17.45 Douglas Stocco (Lubbock, TX, USA)
Expression of the Steroidogenic Acute Regulatory (STAR) protein: A novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse Leydig tumor cells
19.00 DINNER
Friday, September 23
MICROSOMAL P450s: NEW INITIATIVES
Chair: Jean-Guy LeHoux (Sherbrooke, CANADA)
8.30 Virginia Black (New York, NY, USA)
Guinea pig adrenocortical microsomes metabolize androstenedione
in a manner distinct from liver microsomes
8.55 Alain Belanger (Quebec, PQ, CANADA)
Studies on 21-hydroxylase activity in guinea pig adrenal cells in primary culture
9.20 Bon-chu Chung (Taipei, TAIWAN)
Structure, activity, regulation, and promoter function of steroid 21-hydroxylase (P450c21 ) in relation to its deficiency
9.45 Steven Morley (Edinburgh, Scotland, UK)
Adrenal cortex-specific transgene expression directed by mouse steroid 21-hydroxylase promoter
10.10 BREAK
11b-HYDROXYSTEROID DEHYDROGENASE: NEW DEVELOPMENTS
Chair: Paul Stewart (Birmingham, UK)
10.40 Kaiping Yang (London, Ontario, CANADA)
Ovine 11b-hydroxysteroid dehydrogenase: From gene to function
11.05 Anil Agarwal (New York, NY, USA)
Characterization of 11b-hydroxysteroid dehydrogenase (11b-HSD) from sheep kidney
11.30 Brian Walker (Edinburgh, Scotland, UK)
Clinical aspects of 11-hydroxysteroid dehydrogenase
11.55 Zygmunt Krozowski (Prahan, Victoria, AUSTRALIA)
Cloning of the 11b-HSD type II from human kidney
12.20 LUNCH BREAK
13.30 - 14:15 POSTER PRESENTATIONS
CYP11: FAMILY
Chair: Bryan Holland (Galveston,TX, USA)
14:30 Furniko Mitani (Tokyo, JAPAN)
Localization of P450aldo and P45011
b in normal and regenerating rat adrenal cortex14.55 Rita Bernhardt (Berlin, GERMANY)
Localization of cytochrome P45011
b1 in the human adrenal cortex by in-situ hybridization15.20 Perrin White (Dallas, TX, USA)
Haplotype analysis of CYP11B2
15.45 BREAK
ADRENOCORTICAL GENE PRODUCTS
Chair: Michael Waterman (Nashville, TN, USA)
16.15 Roger Sutcliffe (Glasgow, Scotland, UK)
Epitopic heterogeneity in human 3
b-hydroxysteroid dehydrogenase16:40 Yves Tremblay (Quebec, PQ, CANADA)
Studies on the guinea pig adrenal cytochrome P450cl7 cDNA
17.05 Marit Bakke (Huddinge, SWEDEN)
Transcriptional regulation of the bovine CYP17 gene: Two nuclear orphan receptors determine activity of cAMP-responsive sequence 2
17.30 Keith Parker (Durham, NC, USA)
The nuclear receptor SF-1 is essential for the development of steroidogenic tissues.
19.00 CONFERENCE COOKOUT